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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TNKS
All Species:
18.18
Human Site:
S217
Identified Species:
33.33
UniProt:
O95271
Number Species:
12
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95271
NP_003738.2
1327
142039
S217
K
D
M
A
G
R
K
S
S
P
L
H
F
A
A
Chimpanzee
Pan troglodytes
XP_001137443
1327
142033
S217
K
D
M
A
G
R
K
S
S
P
L
H
F
A
A
Rhesus Macaque
Macaca mulatta
XP_001090358
1327
142132
S217
K
D
M
A
G
R
K
S
S
P
L
H
F
A
A
Dog
Lupus familis
XP_849388
1327
142003
S217
K
D
M
A
G
R
K
S
S
P
L
H
F
A
A
Cat
Felis silvestris
Mouse
Mus musculus
NP_780300
1320
140926
S210
K
D
M
A
G
R
K
S
S
P
L
H
F
A
A
Rat
Rattus norvegicus
NP_001101077
1166
126761
P199
K
M
M
A
L
L
T
P
L
N
V
N
C
H
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508887
1320
142724
A233
E
H
L
L
Q
M
G
A
N
V
H
A
R
D
D
Chicken
Gallus gallus
Q5F478
990
107379
E23
I
F
S
G
D
P
E
E
I
R
M
L
I
Y
K
Frog
Xenopus laevis
NP_001088420
1303
140252
A216
E
H
L
L
Q
T
G
A
N
V
H
A
R
D
D
Zebra Danio
Brachydanio rerio
Q502K3
1071
114412
D104
G
A
D
V
T
A
R
D
K
Y
W
Q
T
P
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651410
1181
127927
G208
V
N
C
H
A
S
D
G
R
R
S
T
P
L
H
Honey Bee
Apis mellifera
XP_396483
1166
127309
N199
L
Q
L
L
N
P
L
N
V
N
C
H
A
S
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001186587
1157
126547
E190
E
G
A
R
S
G
N
E
D
K
L
M
S
L
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99.6
98.9
N.A.
96.5
72.2
N.A.
86.8
23.2
87.1
21.8
N.A.
59.4
62.7
N.A.
63.6
Protein Similarity:
100
99.6
99.7
99.1
N.A.
97
80.3
N.A.
89.1
37.4
90.9
37.3
N.A.
71.7
72.8
N.A.
74.6
P-Site Identity:
100
100
100
100
N.A.
100
26.6
N.A.
0
0
0
0
N.A.
0
6.6
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
40
N.A.
26.6
13.3
26.6
6.6
N.A.
6.6
26.6
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
47
8
8
0
16
0
0
0
16
8
39
47
% A
% Cys:
0
0
8
0
0
0
0
0
0
0
8
0
8
0
0
% C
% Asp:
0
39
8
0
8
0
8
8
8
0
0
0
0
16
24
% D
% Glu:
24
0
0
0
0
0
8
16
0
0
0
0
0
0
0
% E
% Phe:
0
8
0
0
0
0
0
0
0
0
0
0
39
0
0
% F
% Gly:
8
8
0
8
39
8
16
8
0
0
0
0
0
0
0
% G
% His:
0
16
0
8
0
0
0
0
0
0
16
47
0
8
8
% H
% Ile:
8
0
0
0
0
0
0
0
8
0
0
0
8
0
0
% I
% Lys:
47
0
0
0
0
0
39
0
8
8
0
0
0
0
8
% K
% Leu:
8
0
24
24
8
8
8
0
8
0
47
8
0
16
16
% L
% Met:
0
8
47
0
0
8
0
0
0
0
8
8
0
0
0
% M
% Asn:
0
8
0
0
8
0
8
8
16
16
0
8
0
0
0
% N
% Pro:
0
0
0
0
0
16
0
8
0
39
0
0
8
8
0
% P
% Gln:
0
8
0
0
16
0
0
0
0
0
0
8
0
0
0
% Q
% Arg:
0
0
0
8
0
39
8
0
8
16
0
0
16
0
0
% R
% Ser:
0
0
8
0
8
8
0
39
39
0
8
0
8
8
0
% S
% Thr:
0
0
0
0
8
8
8
0
0
0
0
8
8
0
0
% T
% Val:
8
0
0
8
0
0
0
0
8
16
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _